Drug interactions
Fosamprenavir + Glipizide
Severity: Moderate
Fosamprenavir and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, through its active metabolite amprenavir, can alter the exposure to glipizide in either direction, and protease inhibitors as a class are associated with insulin resistance and hyperglycemia. Glycemic control may therefore become unpredictable, with a risk of either hypoglycemia or loss of control.
What this interaction means in plain words
Fosamprenavir and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Variable effects on CYP-mediated metabolism of glipizide plus protease inhibitor-related insulin resistance (pharmacodynamic antagonism).
What to do
Monitor blood glucose closely when starting, changing or stopping fosamprenavir. Adjust the glipizide dose according to glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Fosamprenavir with Glipizide?
MediHelp rates the interaction as moderate. Fosamprenavir and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir, through its active metabolite amprenavir, can alter the exposure to glipizide in either direction, and protease inhibitors as a class are associated with insulin resistance and hyperglycemia. Glycemic control may therefore become unpredictable, with a risk of either hypoglycemia or loss of control.
How serious is the interaction between Fosamprenavir and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, changing or stopping fosamprenavir. Adjust the glipizide dose according to glucose readings.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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