Drug interactions
Fosamprenavir + Loratadine
Severity: Minor
Fosamprenavir and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active form of fosamprenavir, inhibits CYP3A4 and may raise loratadine concentrations, particularly when boosted with ritonavir. Loratadine has a wide safety margin, so significant harm is unlikely.
What this interaction means in plain words
Fosamprenavir and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 reduces loratadine metabolism.
What to do
No dose change is routinely required; monitor for sedation and palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Fosamprenavir with Loratadine?
MediHelp rates the interaction as minor. Fosamprenavir and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amprenavir, the active form of fosamprenavir, inhibits CYP3A4 and may raise loratadine concentrations, particularly when boosted with ritonavir. Loratadine has a wide safety margin, so significant harm is unlikely.
How serious is the interaction between Fosamprenavir and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; monitor for sedation and palpitations.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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