Drug interactions
Fosamprenavir + Methylprednisolone
Severity: Moderate
Fosamprenavir and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4 and can increase methylprednisolone exposure, raising the risk of systemic steroid effects including adrenal suppression and Cushingoid features. The reverse effect on antiretroviral levels is minor and of uncertain significance.
What this interaction means in plain words
Fosamprenavir and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4, reducing methylprednisolone clearance.
What to do
Monitor for corticosteroid toxicity and use the lowest effective methylprednisolone dose, especially with prolonged use. Consider an alternative steroid less dependent on CYP3A4 for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Methylprednisolone?
MediHelp rates the interaction as moderate. Fosamprenavir and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4 and can increase methylprednisolone exposure, raising the risk of systemic steroid effects including adrenal suppression and Cushingoid features. The reverse effect on antiretroviral levels is minor and of uncertain significance.
How serious is the interaction between Fosamprenavir and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid toxicity and use the lowest effective methylprednisolone dose, especially with prolonged use. Consider an alternative steroid less dependent on CYP3A4 for long-term therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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