Drug interactions
Fosamprenavir + Nevirapine
Severity: Major
Fosamprenavir and Nevirapine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine lowers amprenavir exposure from fosamprenavir, which may compromise viral suppression. Unboosted fosamprenavir combined with nevirapine is not recommended.
What this interaction means in plain words
Fosamprenavir and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nevirapine induces CYP3A4, increasing amprenavir clearance.
What to do
Avoid unboosted fosamprenavir with nevirapine; if combined, use ritonavir-boosted dosing with HIV RNA monitoring, or choose another regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Fosamprenavir with Nevirapine?
MediHelp rates the interaction as major. Fosamprenavir and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine lowers amprenavir exposure from fosamprenavir, which may compromise viral suppression. Unboosted fosamprenavir combined with nevirapine is not recommended.
How serious is the interaction between Fosamprenavir and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unboosted fosamprenavir with nevirapine; if combined, use ritonavir-boosted dosing with HIV RNA monitoring, or choose another regimen.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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