Drug interactions
Fosamprenavir + Temsirolimus
Severity: Major
Fosamprenavir and Temsirolimus: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, converted to amprenavir, inhibits CYP3A4 (more so with ritonavir) and can raise temsirolimus and sirolimus levels. This raises the risk of toxicity and infection.
What this interaction means in plain words
Fosamprenavir and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 metabolism of temsirolimus and sirolimus.
What to do
Choose an alternative antiretroviral if possible. If unavoidable, consider reducing the temsirolimus dose and monitor closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Temsirolimus?
MediHelp rates the interaction as major. Fosamprenavir and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir, converted to amprenavir, inhibits CYP3A4 (more so with ritonavir) and can raise temsirolimus and sirolimus levels. This raises the risk of toxicity and infection.
How serious is the interaction between Fosamprenavir and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative antiretroviral if possible. If unavoidable, consider reducing the temsirolimus dose and monitor closely.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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