Drug interactions
Fosamprenavir + Trimipramine
Severity: Major
Fosamprenavir and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active form of fosamprenavir, is boosted or given with ritonavir, which inhibits CYP enzymes. Trimipramine levels may rise, increasing sedation, anticholinergic effects and cardiac toxicity.
What this interaction means in plain words
Fosamprenavir and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 and CYP2D6 inhibition, especially with ritonavir boosting, reduces trimipramine clearance.
What to do
Use the lowest effective trimipramine dose and titrate by response. Monitor ECG and tricyclic levels, or choose an alternative antidepressant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Trimipramine?
MediHelp rates the interaction as major. Fosamprenavir and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amprenavir, the active form of fosamprenavir, is boosted or given with ritonavir, which inhibits CYP enzymes. Trimipramine levels may rise, increasing sedation, anticholinergic effects and cardiac toxicity.
How serious is the interaction between Fosamprenavir and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective trimipramine dose and titrate by response. Monitor ECG and tricyclic levels, or choose an alternative antidepressant.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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