Drug interactions
Fosamprenavir + Zileuton
Severity: Minor
Fosamprenavir and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir) is a CYP3A4 inhibitor and may raise zileuton exposure, which is partly metabolized by CYP3A4. Higher zileuton levels could increase adverse effects such as liver enzyme elevation and gastrointestinal upset.
What this interaction means in plain words
Fosamprenavir and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated zileuton metabolism by amprenavir, a modest effect since zileuton has several clearance pathways.
What to do
No empiric dose change is needed; monitor ALT at the usual intervals for zileuton and watch for adverse effects when starting or stopping fosamprenavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Frequently asked questions
Can I take Fosamprenavir with Zileuton?
MediHelp rates the interaction as minor. Fosamprenavir and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosamprenavir (as amprenavir) is a CYP3A4 inhibitor and may raise zileuton exposure, which is partly metabolized by CYP3A4. Higher zileuton levels could increase adverse effects such as liver enzyme elevation and gastrointestinal upset.
How serious is the interaction between Fosamprenavir and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor ALT at the usual intervals for zileuton and watch for adverse effects when starting or stopping fosamprenavir.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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