Drug interactions
Fosaprepitant + Ifosfamide
Severity: Moderate
Fosaprepitant and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor and may alter ifosfamide metabolism. Neurotoxicity with ifosfamide has been reported in patients receiving aprepitant, though causality is not established.
What this interaction means in plain words
Fosaprepitant and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Ifosfamide belongs to Oncology.
Why it happens
CYP3A4 inhibition by aprepitant may change ifosfamide metabolite formation.
What to do
Monitor for neurotoxicity such as confusion, somnolence and hallucinations. Do not withhold antiemetic prophylaxis, but be alert to reduced efficacy or toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Ifosfamide?
MediHelp rates the interaction as moderate. Fosaprepitant and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor and may alter ifosfamide metabolism. Neurotoxicity with ifosfamide has been reported in patients receiving aprepitant, though causality is not established.
How serious is the interaction between Fosaprepitant and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity such as confusion, somnolence and hallucinations. Do not withhold antiemetic prophylaxis, but be alert to reduced efficacy or toxicity.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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