Drug interactions
Fosaprepitant + Imipramine
Severity: Minor
Fosaprepitant and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor. Imipramine is metabolised partly by CYP3A4, so levels could rise slightly. With a single dose of fosaprepitant the effect is expected to be small and transient.
What this interaction means in plain words
Fosaprepitant and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Imipramine belongs to Central Nervous System.
Why it happens
Aprepitant weakly to moderately inhibits CYP3A4, which contributes to imipramine metabolism.
What to do
No routine adjustment is needed. Monitor for anticholinergic and sedative effects if repeated dosing is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Imipramine?
MediHelp rates the interaction as minor. Fosaprepitant and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor. Imipramine is metabolised partly by CYP3A4, so levels could rise slightly. With a single dose of fosaprepitant the effect is expected to be small and transient.
How serious is the interaction between Fosaprepitant and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for anticholinergic and sedative effects if repeated dosing is given.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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