Drug interactions
Fosaprepitant + Irinotecan
Severity: Minor
Fosaprepitant and Irinotecan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor and could modestly increase irinotecan exposure. Studies of aprepitant with irinotecan-based chemotherapy have not shown clinically important changes in irinotecan or SN-38 exposure. The combination is commonly used for antiemetic prophylaxis.
What this interaction means in plain words
Fosaprepitant and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Irinotecan belongs to Oncology.
Why it happens
Aprepitant weakly to moderately inhibits CYP3A4, which could slightly reduce irinotecan oxidative clearance.
What to do
No dose change is usually needed; monitor for diarrhea and neutropenia as per routine irinotecan care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosaprepitant and Irinotecan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Irinotecan?
MediHelp rates the interaction as minor. Fosaprepitant and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor and could modestly increase irinotecan exposure. Studies of aprepitant with irinotecan-based chemotherapy have not shown clinically important changes in irinotecan or SN-38 exposure. The combination is commonly used for antiemetic prophylaxis.
How serious is the interaction between Fosaprepitant and Irinotecan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for diarrhea and neutropenia as per routine irinotecan care.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
