Drug interactions
Fosaprepitant + Lorlatinib
Severity: Moderate
Fosaprepitant and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a CYP3A4 substrate, so lorlatinib may reduce aprepitant exposure and weaken antiemetic protection against chemotherapy-induced nausea.
What this interaction means in plain words
Fosaprepitant and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing aprepitant metabolism.
What to do
Monitor for breakthrough nausea and vomiting and add rescue antiemetics if needed. Consider an alternative antiemetic strategy during prolonged lorlatinib use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Lorlatinib?
MediHelp rates the interaction as moderate. Fosaprepitant and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a CYP3A4 substrate, so lorlatinib may reduce aprepitant exposure and weaken antiemetic protection against chemotherapy-induced nausea.
How serious is the interaction between Fosaprepitant and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add rescue antiemetics if needed. Consider an alternative antiemetic strategy during prolonged lorlatinib use.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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