Drug interactions
Fosaprepitant + Metformin-repaglinide
Severity: Minor
Fosaprepitant and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor that may modestly raise repaglinide levels after single-dose use. The effect is typically small and short-lived, though hypoglycemia is possible.
What this interaction means in plain words
Fosaprepitant and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Metformin-repaglinide belongs to Endocrine.
Why it happens
Transient CYP3A4 inhibition by aprepitant reduces repaglinide metabolism.
What to do
Monitor blood glucose for several days after fosaprepitant, particularly with repeated chemotherapy cycles, and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Metformin-repaglinide?
MediHelp rates the interaction as minor. Fosaprepitant and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor that may modestly raise repaglinide levels after single-dose use. The effect is typically small and short-lived, though hypoglycemia is possible.
How serious is the interaction between Fosaprepitant and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose for several days after fosaprepitant, particularly with repeated chemotherapy cycles, and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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