Drug interactions
Fosaprepitant + Nifedipine
Severity: Minor
Fosaprepitant and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, a prodrug of aprepitant, is a moderate CYP3A4 inhibitor, so nifedipine exposure may increase briefly after a dose. This can produce hypotension or edema.
What this interaction means in plain words
Fosaprepitant and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Nifedipine belongs to Cardiovascular.
Why it happens
Aprepitant transiently inhibits CYP3A4, reducing nifedipine metabolism.
What to do
Monitor blood pressure around the time of fosaprepitant dosing; adjust nifedipine only if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Nifedipine?
MediHelp rates the interaction as minor. Fosaprepitant and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, a prodrug of aprepitant, is a moderate CYP3A4 inhibitor, so nifedipine exposure may increase briefly after a dose. This can produce hypotension or edema.
How serious is the interaction between Fosaprepitant and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure around the time of fosaprepitant dosing; adjust nifedipine only if hypotension occurs.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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