Drug interactions
Fosaprepitant + Pazopanib
Severity: Moderate
Fosaprepitant and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant (aprepitant) is a moderate, dose-dependent CYP3A4 inhibitor given as a short course. A single dose may modestly raise pazopanib exposure, with a possible increase in adverse effects.
What this interaction means in plain words
Fosaprepitant and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Aprepitant, the active metabolite, inhibits CYP3A4 and may reduce pazopanib clearance.
What to do
Usually no dose change is needed for a single antiemetic dose; monitor for pazopanib toxicity such as diarrhea, hypertension and liver enzyme rise. Consider an alternative antiemetic if repeated dosing is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Pazopanib?
MediHelp rates the interaction as moderate. Fosaprepitant and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant (aprepitant) is a moderate, dose-dependent CYP3A4 inhibitor given as a short course. A single dose may modestly raise pazopanib exposure, with a possible increase in adverse effects.
How serious is the interaction between Fosaprepitant and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is needed for a single antiemetic dose; monitor for pazopanib toxicity such as diarrhea, hypertension and liver enzyme rise. Consider an alternative antiemetic if repeated dosing is needed.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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