Drug interactions
Fosaprepitant + Pioglitazone
Severity: Minor
Fosaprepitant and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, given as a single dose, causes only transient, weak to moderate CYP3A4 inhibition. Any rise in pioglitazone exposure is expected to be small and short-lived.
What this interaction means in plain words
Fosaprepitant and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Pioglitazone belongs to Endocrine.
Why it happens
Transient CYP3A4 inhibition by aprepitant, the active metabolite, slightly reducing pioglitazone clearance.
What to do
No dose adjustment is needed; routine glucose monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Pioglitazone?
MediHelp rates the interaction as minor. Fosaprepitant and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, given as a single dose, causes only transient, weak to moderate CYP3A4 inhibition. Any rise in pioglitazone exposure is expected to be small and short-lived.
How serious is the interaction between Fosaprepitant and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; routine glucose monitoring is sufficient.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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