Drug interactions
Fosaprepitant + Prednisolone
Severity: Minor
Fosaprepitant and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, through aprepitant, is a moderate CYP3A4 inhibitor and can increase exposure to CYP3A4-metabolized corticosteroids, mainly dexamethasone and methylprednisolone. Prednisolone is less dependent on this pathway, so the effect is smaller.
What this interaction means in plain words
Fosaprepitant and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Prednisolone belongs to Endocrine.
Why it happens
Aprepitant inhibits CYP3A4, reducing corticosteroid metabolism.
What to do
No routine dose change is needed for prednisolone with a single fosaprepitant dose. Monitor for steroid adverse effects if repeated dosing occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Prednisolone?
MediHelp rates the interaction as minor. Fosaprepitant and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, through aprepitant, is a moderate CYP3A4 inhibitor and can increase exposure to CYP3A4-metabolized corticosteroids, mainly dexamethasone and methylprednisolone. Prednisolone is less dependent on this pathway, so the effect is smaller.
How serious is the interaction between Fosaprepitant and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for prednisolone with a single fosaprepitant dose. Monitor for steroid adverse effects if repeated dosing occurs.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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