Drug interactions
Fosaprepitant + Sunitinib
Severity: Minor
Fosaprepitant and Sunitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant formed from fosaprepitant is a moderate CYP3A4 inhibitor, but a single dose gives only a transient effect. Sunitinib exposure may rise modestly, with limited clinical consequence.
What this interaction means in plain words
Fosaprepitant and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Sunitinib belongs to Oncology.
Why it happens
Transient, weak-to-moderate CYP3A4 inhibition by aprepitant.
What to do
No routine adjustment is needed with single-dose use; watch for increased sunitinib adverse effects if repeated dosing is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Sunitinib?
MediHelp rates the interaction as minor. Fosaprepitant and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant formed from fosaprepitant is a moderate CYP3A4 inhibitor, but a single dose gives only a transient effect. Sunitinib exposure may rise modestly, with limited clinical consequence.
How serious is the interaction between Fosaprepitant and Sunitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed with single-dose use; watch for increased sunitinib adverse effects if repeated dosing is given.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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