Drug interactions
Fosaprepitant + Vincristine
Severity: Moderate
Fosaprepitant and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor and could modestly raise vincristine exposure. With single-dose use the effect is likely small, but neurotoxicity may be increased.
What this interaction means in plain words
Fosaprepitant and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Vincristine belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing vincristine metabolism.
What to do
Monitor for neuropathy and constipation during treatment. Reduce the vincristine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Vincristine?
MediHelp rates the interaction as moderate. Fosaprepitant and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor and could modestly raise vincristine exposure. With single-dose use the effect is likely small, but neurotoxicity may be increased.
How serious is the interaction between Fosaprepitant and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy and constipation during treatment. Reduce the vincristine dose if toxicity develops.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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