Drug interactions
Fosaprepitant + Vinorelbine
Severity: Minor
Fosaprepitant and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor, but with a single dose the effect on vinorelbine is expected to be small. Aprepitant is often given with chemotherapy without major problems.
What this interaction means in plain words
Fosaprepitant and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Vinorelbine belongs to Oncology.
Why it happens
Weak to moderate, transient inhibition of CYP3A4 by aprepitant.
What to do
No dose adjustment is usually needed. Monitor for neutropenia and neuropathy as per routine vinorelbine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Vinorelbine?
MediHelp rates the interaction as minor. Fosaprepitant and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor, but with a single dose the effect on vinorelbine is expected to be small. Aprepitant is often given with chemotherapy without major problems.
How serious is the interaction between Fosaprepitant and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for neutropenia and neuropathy as per routine vinorelbine care.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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