Drug interactions
Foscarnet + Iloperidone
Severity: Major
Foscarnet and Iloperidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and foscarnet may also cause hypocalcemia, hypomagnesemia and hypokalemia that increase proarrhythmic risk. Iloperidone carries a labeled warning about QT prolongation with other QT-prolonging agents. The combination raises the risk of torsades de pointes.
What this interaction means in plain words
Foscarnet and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation with electrolyte disturbances caused by foscarnet.
What to do
Avoid the combination if an alternative antipsychotic or antiviral is possible. If used together, monitor ECG and keep potassium, magnesium and calcium within normal ranges.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Foscarnet with Iloperidone?
MediHelp rates the interaction as major. Foscarnet and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and foscarnet may also cause hypocalcemia, hypomagnesemia and hypokalemia that increase proarrhythmic risk. Iloperidone carries a labeled warning about QT prolongation with other QT-prolonging agents. The combination raises the risk of torsades de pointes.
How serious is the interaction between Foscarnet and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antipsychotic or antiviral is possible. If used together, monitor ECG and keep potassium, magnesium and calcium within normal ranges.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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