Drug interactions
Foscarnet + Macimorelin
Severity: Major
Foscarnet and Macimorelin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a modest QT prolongation and is not recommended with other QT-prolonging drugs. Foscarnet also prolongs QT and may disturb electrolytes, so combined exposure could increase torsade de pointes risk during the diagnostic test.
What this interaction means in plain words
Foscarnet and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Macimorelin belongs to Endocrine.
Why it happens
Additive QT prolongation, with foscarnet-related electrolyte disturbances contributing.
What to do
Postpone macimorelin testing until foscarnet has been stopped and sufficiently cleared, or use an alternative diagnostic test. If testing cannot be delayed, check ECG and electrolytes first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Foscarnet with Macimorelin?
MediHelp rates the interaction as major. Foscarnet and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a modest QT prolongation and is not recommended with other QT-prolonging drugs. Foscarnet also prolongs QT and may disturb electrolytes, so combined exposure could increase torsade de pointes risk during the diagnostic test.
How serious is the interaction between Foscarnet and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone macimorelin testing until foscarnet has been stopped and sufficiently cleared, or use an alternative diagnostic test. If testing cannot be delayed, check ECG and electrolytes first.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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