Drug interactions
Foscarnet + Osilodrostat
Severity: Moderate
Foscarnet and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat is associated with QT prolongation and can cause hypokalemia, and foscarnet also prolongs QT and disturbs electrolytes. Combined use increases the potential for torsades de pointes.
What this interaction means in plain words
Foscarnet and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT interval prolongation with electrolyte disturbances from both drugs.
What to do
Obtain a baseline ECG and repeat during co-therapy. Maintain potassium and magnesium in the normal range and reduce or stop osilodrostat if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Foscarnet with Osilodrostat?
MediHelp rates the interaction as moderate. Foscarnet and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat is associated with QT prolongation and can cause hypokalemia, and foscarnet also prolongs QT and disturbs electrolytes. Combined use increases the potential for torsades de pointes.
How serious is the interaction between Foscarnet and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat during co-therapy. Maintain potassium and magnesium in the normal range and reduce or stop osilodrostat if QT prolongation develops.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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