Drug interactions
Foscarnet + Osimertinib
Severity: Moderate
Foscarnet and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and foscarnet has QT-prolonging effects plus the potential to cause hypocalcemia, hypomagnesemia and hypokalemia. Combined use may raise the risk of serious arrhythmia.
What this interaction means in plain words
Foscarnet and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation, worsened by foscarnet-related electrolyte disturbances.
What to do
Monitor ECG and electrolytes periodically and correct abnormalities. Consider withholding osimertinib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Foscarnet with Osimertinib?
MediHelp rates the interaction as moderate. Foscarnet and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval, and foscarnet has QT-prolonging effects plus the potential to cause hypocalcemia, hypomagnesemia and hypokalemia. Combined use may raise the risk of serious arrhythmia.
How serious is the interaction between Foscarnet and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically and correct abnormalities. Consider withholding osimertinib if the QTc becomes markedly prolonged.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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