Drug interactions
Foscarnet + Oxaliplatin
Severity: Major
Foscarnet and Oxaliplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin can prolong the QT interval and cause hypokalemia and hypomagnesemia, and foscarnet adds QT and electrolyte effects. Together they raise the risk of ventricular arrhythmias, and both are potentially nephrotoxic.
What this interaction means in plain words
Foscarnet and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation and additive electrolyte depletion.
What to do
Avoid if an alternative exists; otherwise monitor ECG, renal function, potassium, magnesium and calcium frequently and replace as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Foscarnet with Oxaliplatin?
MediHelp rates the interaction as major. Foscarnet and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxaliplatin can prolong the QT interval and cause hypokalemia and hypomagnesemia, and foscarnet adds QT and electrolyte effects. Together they raise the risk of ventricular arrhythmias, and both are potentially nephrotoxic.
How serious is the interaction between Foscarnet and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists; otherwise monitor ECG, renal function, potassium, magnesium and calcium frequently and replace as needed.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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