Drug interactions
Foscarnet + Solifenacin
Severity: Moderate
Foscarnet and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet can prolong the QT interval and causes electrolyte disturbances such as hypocalcemia, hypomagnesemia and hypokalemia. Together with solifenacin, this increases the risk of ventricular arrhythmia.
What this interaction means in plain words
Foscarnet and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, with foscarnet-induced electrolyte depletion as an amplifier.
What to do
Monitor electrolytes and replace deficits during foscarnet therapy, and check the ECG. Hold solifenacin if QTc prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Solifenacin?
MediHelp rates the interaction as moderate. Foscarnet and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet can prolong the QT interval and causes electrolyte disturbances such as hypocalcemia, hypomagnesemia and hypokalemia. Together with solifenacin, this increases the risk of ventricular arrhythmia.
How serious is the interaction between Foscarnet and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes and replace deficits during foscarnet therapy, and check the ECG. Hold solifenacin if QTc prolongation develops.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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