Drug interactions
Foscarnet + Vorinostat
Severity: Major
Foscarnet and Vorinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and foscarnet can also prolong the QT interval and disturb electrolytes. Using them together may increase the risk of torsade de pointes.
What this interaction means in plain words
Foscarnet and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Vorinostat belongs to Oncology.
Why it happens
Additive QT prolongation, with foscarnet-induced electrolyte disturbances contributing.
What to do
Avoid the combination where an alternative exists. If both are needed, check baseline ECG and electrolytes and monitor both during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Foscarnet with Vorinostat?
MediHelp rates the interaction as major. Foscarnet and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorinostat has been associated with QT prolongation, and foscarnet can also prolong the QT interval and disturb electrolytes. Using them together may increase the risk of torsade de pointes.
How serious is the interaction between Foscarnet and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If both are needed, check baseline ECG and electrolytes and monitor both during therapy.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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