Drug interactions
Fosinopril + Furosemide
Severity: Moderate
Fosinopril and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Starting fosinopril in a patient taking furosemide can lead to first-dose hypotension and acute worsening of renal function, especially with volume or sodium depletion. The combination is often used therapeutically with careful initiation.
What this interaction means in plain words
Fosinopril and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of diuretic-induced volume depletion and ACE inhibition reducing angiotensin II-dependent renal perfusion.
What to do
Start with a low fosinopril dose and consider temporarily reducing the furosemide dose. Monitor blood pressure, creatinine and potassium in the first one to two weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril and Furosemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Furosemide?
MediHelp rates the interaction as moderate. Fosinopril and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Starting fosinopril in a patient taking furosemide can lead to first-dose hypotension and acute worsening of renal function, especially with volume or sodium depletion. The combination is often used therapeutically with careful initiation.
How serious is the interaction between Fosinopril and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low fosinopril dose and consider temporarily reducing the furosemide dose. Monitor blood pressure, creatinine and potassium in the first one to two weeks.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
