Drug interactions
Fosinopril + Insulin glargine
Severity: Moderate
Fosinopril and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and so enhance the glucose-lowering effect of insulin. Hypoglycemia is most likely after starting or increasing fosinopril.
What this interaction means in plain words
Fosinopril and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Insulin glargine belongs to Endocrine.
Why it happens
ACE inhibition may improve peripheral insulin sensitivity, adding to the effect of exogenous insulin.
What to do
Monitor blood glucose more frequently when fosinopril is started or titrated. Lower the insulin glargine dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Insulin glargine
Frequently asked questions
Can I take Fosinopril with Insulin glargine?
MediHelp rates the interaction as moderate. Fosinopril and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and so enhance the glucose-lowering effect of insulin. Hypoglycemia is most likely after starting or increasing fosinopril.
How serious is the interaction between Fosinopril and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when fosinopril is started or titrated. Lower the insulin glargine dose if hypoglycemia occurs.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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