Drug interactions
Fosinopril + Lornoxicam
Severity: Moderate
Fosinopril and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam may reduce the antihypertensive effect of fosinopril. The combination also increases the risk of acute kidney injury and hyperkalemia, especially in the elderly or dehydrated.
What this interaction means in plain words
Fosinopril and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal blood flow, opposing ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective lornoxicam dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Fosinopril with Lornoxicam?
MediHelp rates the interaction as moderate. Fosinopril and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam may reduce the antihypertensive effect of fosinopril. The combination also increases the risk of acute kidney injury and hyperkalemia, especially in the elderly or dehydrated.
How serious is the interaction between Fosinopril and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective lornoxicam dose for the shortest duration.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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