Drug interactions
Fosinopril + Perphenazine
Severity: Minor
Fosinopril and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can cause orthostatic hypotension, and combined use with fosinopril may add to blood pressure lowering. The effect is usually modest.
What this interaction means in plain words
Fosinopril and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Fosinopril with Perphenazine?
MediHelp rates the interaction as minor. Fosinopril and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine can cause orthostatic hypotension, and combined use with fosinopril may add to blood pressure lowering. The effect is usually modest.
How serious is the interaction between Fosinopril and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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