Drug interactions
Fosinopril + Potassium iodide
Severity: Moderate
Fosinopril and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide provides a potassium load, and ACE inhibitors reduce potassium excretion through aldosterone suppression. Hyperkalemia may result, mainly with prolonged or high-dose iodide use or reduced kidney function.
What this interaction means in plain words
Fosinopril and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Potassium iodide belongs to Endocrine.
Why it happens
ACE inhibition reduces aldosterone-dependent renal potassium excretion, adding to potassium from the iodide salt.
What to do
Monitor serum potassium when potassium iodide is used for more than brief periods, especially with renal impairment. Stop or reduce iodide if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Fosinopril with Potassium iodide?
MediHelp rates the interaction as moderate. Fosinopril and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide provides a potassium load, and ACE inhibitors reduce potassium excretion through aldosterone suppression. Hyperkalemia may result, mainly with prolonged or high-dose iodide use or reduced kidney function.
How serious is the interaction between Fosinopril and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when potassium iodide is used for more than brief periods, especially with renal impairment. Stop or reduce iodide if hyperkalemia develops.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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