Drug interactions
Fosinopril-hydrochlorothiazide + Indomethacin
Severity: Moderate
Fosinopril-hydrochlorothiazide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin notably attenuates the antihypertensive effect of ACE inhibitors and diuretics. Combined use raises the risk of renal impairment and hyperkalemia, particularly in volume-depleted or elderly patients.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, antagonizing ACE inhibitor and thiazide effects.
What to do
Use an alternative analgesic if possible. If unavoidable, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Indomethacin?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin notably attenuates the antihypertensive effect of ACE inhibitors and diuretics. Combined use raises the risk of renal impairment and hyperkalemia, particularly in volume-depleted or elderly patients.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative analgesic if possible. If unavoidable, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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