Drug interactions
Fosinopril-hydrochlorothiazide + Methoxsalen
Severity: Moderate
Fosinopril-hydrochlorothiazide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a recognized photosensitizer, and methoxsalen is used to deliberately induce photosensitivity in PUVA therapy. Combined use may intensify phototoxic reactions such as severe erythema and burns.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive phototoxicity from two photosensitizing drugs.
What to do
Review UV exposure and consider adjusting the PUVA dose or an alternative antihypertensive. Counsel on sun protection and watch for exaggerated skin reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Methoxsalen?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a recognized photosensitizer, and methoxsalen is used to deliberately induce photosensitivity in PUVA therapy. Combined use may intensify phototoxic reactions such as severe erythema and burns.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review UV exposure and consider adjusting the PUVA dose or an alternative antihypertensive. Counsel on sun protection and watch for exaggerated skin reactions.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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