Drug interactions
Fosinopril-hydrochlorothiazide + Nadolol
Severity: Minor
Fosinopril-hydrochlorothiazide and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol and this ACE inhibitor-thiazide combination lower blood pressure additively, which is often therapeutic but may cause hypotension or bradycardia. Nadolol is renally cleared and dehydration or renal impairment from the diuretic may raise its levels.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with possible reduced nadolol clearance if renal function declines.
What to do
Monitor blood pressure, heart rate and renal function, and reduce nadolol dose if renal function worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Nadolol
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Nadolol?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol and this ACE inhibitor-thiazide combination lower blood pressure additively, which is often therapeutic but may cause hypotension or bradycardia. Nadolol is renally cleared and dehydration or renal impairment from the diuretic may raise its levels.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and renal function, and reduce nadolol dose if renal function worsens.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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