Drug interactions
Fosinopril-hydrochlorothiazide + Oliceridine
Severity: Moderate
Fosinopril-hydrochlorothiazide and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may promote antidiuretic hormone release and reduce diuretic efficacy. They can also cause hypotension, which may add to the antihypertensive effects.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Opioid-induced ADH release reduces diuresis, with additive hypotensive effects.
What to do
Monitor fluid status and blood pressure. Increase the diuretic dose if diuresis is diminished.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Oliceridine?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids may promote antidiuretic hormone release and reduce diuretic efficacy. They can also cause hypotension, which may add to the antihypertensive effects.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid status and blood pressure. Increase the diuretic dose if diuresis is diminished.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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