Drug interactions
Fosinopril-hydrochlorothiazide + Pivmecillinam
Severity: Minor
Fosinopril-hydrochlorothiazide and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pivmecillinam's active form, mecillinam, is cleared by the kidney, and thiazides may modestly reduce renal tubular handling of some penicillins. Clinically significant changes in exposure are not well documented and the interaction is likely small.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion, plus thiazide-related volume depletion reducing renal clearance; poorly established.
What to do
No routine adjustment is needed; monitor renal function and clinical response if the patient is volume depleted or has renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Pivmecillinam?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pivmecillinam's active form, mecillinam, is cleared by the kidney, and thiazides may modestly reduce renal tubular handling of some penicillins. Clinically significant changes in exposure are not well documented and the interaction is likely small.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function and clinical response if the patient is volume depleted or has renal impairment.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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