Drug interactions
Fosinopril-hydrochlorothiazide + Potassium citrate
Severity: Moderate
Fosinopril-hydrochlorothiazide and Potassium citrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce aldosterone and retain potassium, so supplemental potassium can lead to hyperkalemia, especially with renal impairment or diabetes. The thiazide partly offsets this by increasing potassium loss, so the net effect is unpredictable.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Potassium citrate belongs to Gastrointestinal Tract.
Why it happens
Reduced aldosterone-mediated potassium excretion from ACE inhibition combined with potassium load, partly offset by thiazide kaliuresis.
What to do
Check serum potassium and renal function within the first weeks and periodically afterward. Adjust or stop the potassium citrate if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Potassium citrate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Potassium citrate?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors reduce aldosterone and retain potassium, so supplemental potassium can lead to hyperkalemia, especially with renal impairment or diabetes. The thiazide partly offsets this by increasing potassium loss, so the net effect is unpredictable.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Potassium citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function within the first weeks and periodically afterward. Adjust or stop the potassium citrate if potassium rises.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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