Drug interactions
Fosinopril-hydrochlorothiazide + Prednisone
Severity: Moderate
Fosinopril-hydrochlorothiazide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and prednisone both increase urinary potassium loss, so combined use can lead to additive hypokalemia. This is of greater concern in patients with heart disease or on digoxin or QT-prolonging drugs.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide and corticosteroid effects.
What to do
Monitor serum potassium during prolonged or high-dose steroid therapy and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Prednisone?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide and prednisone both increase urinary potassium loss, so combined use can lead to additive hypokalemia. This is of greater concern in patients with heart disease or on digoxin or QT-prolonging drugs.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during prolonged or high-dose steroid therapy and replace potassium as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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