Drug interactions
Fosinopril-hydrochlorothiazide + Probenecid
Severity: Minor
Fosinopril-hydrochlorothiazide and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid blocks the renal tubular secretion of hydrochlorothiazide, which may raise thiazide exposure. Thiazides can also raise uric acid, opposing the uricosuric effect of probenecid. The practical impact is usually modest.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for organic anion transporters in the renal tubule reduces thiazide secretion, and thiazide-induced urate retention counteracts probenecid.
What to do
Monitor blood pressure, electrolytes and serum uric acid, and adjust probenecid dose if urate control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Probenecid?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid blocks the renal tubular secretion of hydrochlorothiazide, which may raise thiazide exposure. Thiazides can also raise uric acid, opposing the uricosuric effect of probenecid. The practical impact is usually modest.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and serum uric acid, and adjust probenecid dose if urate control is inadequate.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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