Drug interactions
Fosinopril-hydrochlorothiazide + Sitagliptin
Severity: Minor
Fosinopril-hydrochlorothiazide and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may raise blood glucose and slightly blunt the glycemic benefit of sitagliptin. The effect is generally small at the low doses found in fixed-dose combinations.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazides impair insulin secretion and reduce insulin sensitivity.
What to do
Monitor blood glucose and HbA1c after starting or raising the thiazide dose. Intensify antidiabetic therapy only if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Sitagliptin?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may raise blood glucose and slightly blunt the glycemic benefit of sitagliptin. The effect is generally small at the low doses found in fixed-dose combinations.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or raising the thiazide dose. Intensify antidiabetic therapy only if control deteriorates.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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