Drug interactions
Fosinopril-hydrochlorothiazide + Sulindac
Severity: Moderate
Fosinopril-hydrochlorothiazide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac may blunt the antihypertensive effect of fosinopril and hydrochlorothiazide. Its renal prostaglandin-sparing effect is less certain than other NSAIDs, but renal impairment and hyperkalemia can still occur, especially in at-risk patients.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis can reduce renal perfusion and sodium excretion, opposing ACE inhibitor and thiazide effects.
What to do
Prefer a non-NSAID analgesic. If used, choose the lowest effective dose and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Sulindac?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac may blunt the antihypertensive effect of fosinopril and hydrochlorothiazide. Its renal prostaglandin-sparing effect is less certain than other NSAIDs, but renal impairment and hyperkalemia can still occur, especially in at-risk patients.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic. If used, choose the lowest effective dose and monitor blood pressure, creatinine and potassium.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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