Drug interactions
Fosinopril-hydrochlorothiazide + Tolazamide
Severity: Moderate
Fosinopril-hydrochlorothiazide and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and enhance the glucose-lowering action of sulfonylureas, raising hypoglycemia risk. Thiazides tend to oppose this by raising glucose, so the net effect varies.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
ACE inhibitors may increase insulin sensitivity, adding to sulfonylurea effect, while thiazide diuretics cause hyperglycemia.
What to do
Monitor blood glucose when starting or stopping the combination and reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Tolazamide?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and enhance the glucose-lowering action of sulfonylureas, raising hypoglycemia risk. Thiazides tend to oppose this by raising glucose, so the net effect varies.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the combination and reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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