Drug interactions
Fosinopril-hydrochlorothiazide + Tolbutamide
Severity: Moderate
Fosinopril-hydrochlorothiazide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. Hydrochlorothiazide may raise glucose and partly counteract this, making control less predictable.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
ACE inhibitors may improve insulin sensitivity, adding to sulfonylurea effect, while thiazides impair glucose tolerance.
What to do
Monitor blood glucose after starting or changing therapy and adjust the tolbutamide dose if hypoglycemia or hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Tolbutamide?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. Hydrochlorothiazide may raise glucose and partly counteract this, making control less predictable.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing therapy and adjust the tolbutamide dose if hypoglycemia or hyperglycemia develops.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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