Drug interactions
Fosphenytoin + Vortioxetine
Severity: Moderate
Fosphenytoin and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, a broad enzyme inducer that can lower vortioxetine concentrations. This may lead to loss of antidepressant effect and relapse of depressive symptoms.
What this interaction means in plain words
Fosphenytoin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosphenytoin belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP enzymes (including CYP3A4 and CYP2C9) involved in vortioxetine metabolism, increasing its clearance.
What to do
Monitor clinical response to vortioxetine and consider increasing the dose, up to a maximum of triple the usual dose, when a strong inducer is used long term. Reduce vortioxetine back to the original dose within about 14 days of stopping the inducer.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fosphenytoin with Vortioxetine?
MediHelp rates the interaction as moderate. Fosphenytoin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosphenytoin is converted to phenytoin, a broad enzyme inducer that can lower vortioxetine concentrations. This may lead to loss of antidepressant effect and relapse of depressive symptoms.
How serious is the interaction between Fosphenytoin and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to vortioxetine and consider increasing the dose, up to a maximum of triple the usual dose, when a strong inducer is used long term. Reduce vortioxetine back to the original dose within about 14 days of stopping the inducer.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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