Drug interactions
Fostamatinib + Hydrocortisone
Severity: Minor
Fostamatinib and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite, tamatinib, inhibits P-glycoprotein and may raise concentrations of P-gp substrates. Hydrocortisone is a P-gp substrate, but the expected increase in exposure is likely modest. Clinical significance is uncertain.
What this interaction means in plain words
Fostamatinib and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Hydrocortisone belongs to Endocrine.
Why it happens
Tamatinib inhibits intestinal and cellular P-glycoprotein efflux, potentially increasing hydrocortisone exposure.
What to do
No routine dose change is needed. Monitor for excess corticosteroid effects such as hyperglycemia or fluid retention during long-term co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Hydrocortisone?
MediHelp rates the interaction as minor. Fostamatinib and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite, tamatinib, inhibits P-glycoprotein and may raise concentrations of P-gp substrates. Hydrocortisone is a P-gp substrate, but the expected increase in exposure is likely modest. Clinical significance is uncertain.
How serious is the interaction between Fostamatinib and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for excess corticosteroid effects such as hyperglycemia or fluid retention during long-term co-therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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