Drug interactions
Fostamatinib + Metformin-sitagliptin
Severity: Minor
Fostamatinib and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and can raise concentrations of P-gp substrates such as sitagliptin. Sitagliptin has a wide therapeutic index, so the clinical effect is usually modest.
What this interaction means in plain words
Fostamatinib and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by the active metabolite tamatinib increases sitagliptin exposure.
What to do
No dose change is normally required for sitagliptin; monitor for adverse effects such as GI upset or hypoglycemia if other glucose-lowering drugs are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Fostamatinib and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits P-glycoprotein and can raise concentrations of P-gp substrates such as sitagliptin. Sitagliptin has a wide therapeutic index, so the clinical effect is usually modest.
How serious is the interaction between Fostamatinib and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally required for sitagliptin; monitor for adverse effects such as GI upset or hypoglycemia if other glucose-lowering drugs are used.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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