Drug interactions
Fostamatinib + Tenofovir disoproxil
Severity: Minor
Fostamatinib and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits BCRP and can increase exposure to BCRP substrates. Tenofovir exposure may rise modestly.
What this interaction means in plain words
Fostamatinib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal BCRP by the active metabolite of fostamatinib (tamatinib), increasing tenofovir absorption.
What to do
No routine dose change is needed. Monitor renal function and tenofovir-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Fostamatinib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits BCRP and can increase exposure to BCRP substrates. Tenofovir exposure may rise modestly.
How serious is the interaction between Fostamatinib and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor renal function and tenofovir-related adverse effects.
What other medicines interact with Fostamatinib?
MediHelp also lists interactions of Fostamatinib with, for example, Colchicine, Phenytoin, Amobarbital. The full list is on the Fostamatinib page.
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