Drug interactions
Fostemsavir + Memantine-donepezil
Severity: Minor
Fostemsavir and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval, and fostemsavir has caused QT prolongation at supratherapeutic doses. At the recommended dose the effect of fostemsavir is small, so the combined risk is modest but may matter in patients with other arrhythmia risk factors.
What this interaction means in plain words
Fostemsavir and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostemsavir belongs to Anti Virals; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Potential additive effect on cardiac repolarization (QT prolongation).
What to do
No routine dose change is needed at recommended doses. Consider an ECG in patients with existing QT risk, bradycardia or electrolyte disturbances.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Memantine-donepezil?
MediHelp rates the interaction as minor. Fostemsavir and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Donepezil can prolong the QT interval, and fostemsavir has caused QT prolongation at supratherapeutic doses. At the recommended dose the effect of fostemsavir is small, so the combined risk is modest but may matter in patients with other arrhythmia risk factors.
How serious is the interaction between Fostemsavir and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed at recommended doses. Consider an ECG in patients with existing QT risk, bradycardia or electrolyte disturbances.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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