Drug interactions
Fostemsavir + Oxytocin
Severity: Moderate
Fostemsavir and Oxytocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxytocin has been associated with QT prolongation, and fostemsavir at supratherapeutic doses prolongs the QTc interval. Using them together could add to the risk of arrhythmia, particularly in patients with other risk factors. At recommended fostemsavir doses the effect is small.
What this interaction means in plain words
Fostemsavir and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Oxytocin belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization and QTc prolongation.
What to do
Obtain an ECG if the patient has other QT risk factors such as congenital long QT, bradycardia or electrolyte disturbance, and correct potassium and magnesium. Keep fostemsavir at the recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxytocin
- Carboprost tromethamine + Oxytocin Major
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Oxytocin?
MediHelp rates the interaction as moderate. Fostemsavir and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxytocin has been associated with QT prolongation, and fostemsavir at supratherapeutic doses prolongs the QTc interval. Using them together could add to the risk of arrhythmia, particularly in patients with other risk factors. At recommended fostemsavir doses the effect is small.
How serious is the interaction between Fostemsavir and Oxytocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG if the patient has other QT risk factors such as congenital long QT, bradycardia or electrolyte disturbance, and correct potassium and magnesium. Keep fostemsavir at the recommended dose.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Carboprost tromethamine, Dinoprostone, Ephedrine. The full list is on the Oxytocin page.
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