Drug interactions
Fostemsavir + Propafenone
Severity: Moderate
Fostemsavir and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone prolongs the QT interval, and fostemsavir has caused QT prolongation at supratherapeutic doses. Together they may add to the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Fostemsavir and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Propafenone belongs to Cardiovascular.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG, correct electrolyte abnormalities, and monitor QTc during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Propafenone?
MediHelp rates the interaction as moderate. Fostemsavir and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone prolongs the QT interval, and fostemsavir has caused QT prolongation at supratherapeutic doses. Together they may add to the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Fostemsavir and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct electrolyte abnormalities, and monitor QTc during co-therapy.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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